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KMID : 0381219870190030262
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Journal of RIMSK
1987 Volume.19 No. 3 p.262 ~ p.265
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The Effect of Cholestyramine Upon Acute Infantile Diarrhea Due to Rotavirus Infection
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Abstract
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A clinical trial for the therapeutic effect of cholestyramine upon acute infantile diarrhea due to rotavirus infection was conducted on 32 patients who were admitted to pediatric department of Chung-Ang University Hospital from Oct 1, 1986 to Dec 12, 1986.
In addition to conservative treatment, cholestyramine 2 gm twice daily was randomly administered to 17 of the patients and compared the duration and the frequency of diarrhea after treatment between study (cholestyramine) group and control group.
The results were as follows:
1) The duration of watery diarrhea after treatment was 2.2±1.4 days in the study group and 3.2± 1.5 days in the control group (P<0.02).
2) The mean daily frequency of watery diarrhea after treatment was 2.5, 2.4 and 1.5 times on 1st, 2nd and 3rd hospital day, respectively in the study group and 3.2, 3.0 and 2.7 times on 1st, 2nd and 3rd hospital day, respectively in the control group (P<0.02).
In conclusion that cholestyramine therapy can be safely used to shorten the duration of diarrhea and to reduce the frequency of acute watery diarrhea due to rotavirus infection in infants.
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